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ONYX PHARMACEUTICALS, INC. v. BAYER CORP., 863 F.Supp.2d 894 (2011)

Court: District Court, N.D. California Number: inadvfdco121219000073 Visitors: 11
Filed: Sep. 21, 2011
Latest Update: Sep. 21, 2011
Summary: FINAL PRETRIAL CONFERENCE ORDER EDWARD M. CHEN, District Judge. A Final Pretrial Conference was held in this matter on September 20, 2011. Pursuant to Federal Rule of Civil Procedure 16(e), this order memorializes the Court's rulings and/or the parties' stipulations. Also attached are the Court's standing Guidelines for Trial. I. TRIAL DATE & LENGTH OF TRIAL The trial shall begin on October 3, 2011, Courtroom 5, 17th Floor. There shall be a total of twelve court days. Trial shall be con
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FINAL PRETRIAL CONFERENCE ORDER

EDWARD M. CHEN, District Judge.

A Final Pretrial Conference was held in this matter on September 20, 2011. Pursuant to Federal Rule of Civil Procedure 16(e), this order memorializes the Court's rulings and/or the parties' stipulations. Also attached are the Court's standing Guidelines for Trial.

I. TRIAL DATE & LENGTH OF TRIAL

The trial shall begin on October 3, 2011, Courtroom 5, 17th Floor. There shall be a total of twelve court days.

Trial shall be conducted from 8:30 a.m. to 2:00 p.m. (or slightly longer to finish a witness), with one 15-minute break and one 40-minute lunch break. Parties must arrive by 8:00 a.m. or earlier as needed for any matters to be heard out of the presence of the jury. The jury will be called at 8:30 a.m. The trial week is Monday through Thursday, excluding holidays. Fridays are dark. If there are matters that need to be discussed (e.g., objections to exhibits or witnesses), counsel should be prepared to meet with the Court at 8:00 a.m.

Plaintiff shall have 22 hours to present her evidence, and Defendant 22 hours. This includes direct examination by one side of its witnesses, cross-examination by that side of the opposing party's witnesses, and any rebuttal. This does not include jury selection, jury instructions, opening statements, or closing arguments. The Court may impose separate time limits for openings and closings.

II. MOTIONS IN LIMINE

A. Defendant's Motion in Limine (Docket No. 140)

Bayer's Motion in Limine requests that the Court exclude four categories of evidence. For the reasons set forth below, the Court DENIES the motion without prejudice.

1. Evidence of Negotiators' Unexpressed Intent

Bayer seeks to prevent Onyx from introducing evidence as to the unexpressed intent and understanding of Onyx's negotiators to the Collaboration Agreement. Mot. in Limine, Docket No. 140 ("Mot."), at 1. These witnesses are Frank McCormick, Bob Jones, and Hollings Renton. Bayer contends that their testimony as to the meaning of the contract is inadmissible under Rule 402 and 403 because they merely testify as to their own subjective, which is irrelevant under California law. Mot. at 2. Bayer asks the Court to restrict the testimony of these witnesses to objective, expressed intent rather than subjective, understood intent. Onyx counters that these witnesses will testify not as to their subjective intent, but rather the parties' mutual intent and understanding of the contract terms. It argues that the witnesses are permitted to testify as to expressed and unexpressed representations during the course of negotiations. Opp. at 1.

Bayer overstates California law's restrictions on witness testimony as to a contract's meaning under the objective theory of contracts. Bayer seeks to exclude these witnesses' testimony based on their admissions at some point in their depositions that they did not recall "specific discussions" during the course of negotiations as to the meaning of certain specific words in the contract. See Mot. at 2-3 (citing portions of Renton depo.); id. at 4 (citing portions of McCormick depo.); id. (citing portions of Jones depo.). However, contrary to Bayer's implication, these admissions do not amount to any broad concession that these witnesses remember nothing from the negotiations that would inform their memory of and testimony as to the parties' expressed intent. A lack of specific recollection does not change the nature of the testimony, only its weight. None of the cases to which Bayer cites require witnesses to quote from negotiations or provide a detailed account of "specific discussions" in order to testify as to their memory of those negotiations. For example, Bayer cites to Founding Members of Newport Beach Country Club v. Newport Beach Country Club, Inc., 109 Cal.App.4th 944, 960, 135 Cal.Rptr.2d 505 (2003). However, Founding Members does not stand for the broad proposition that all testimony as to a negotiator's understanding of contract terms is inadmissible. Rather, Founding Members merely holds that conversations between members of the same side in a negotiation, conversations between those persons and a sales assistant, conversations with undisclosed third parties, and undisclosed statements of individual intent are not relevant under the "objective theory of contracts." Id. Other cases on which Bayer relies for support similarly do not discuss or require the specificity it requests that this Court impose. See Winet v. Price, 4 Cal.App.4th 1159, 1166, 6 Cal.Rptr.2d 554 (1992) (disregarding "testimony as to what [the witness] subjectively understood and intended the release to encompass"); Habitat Trust for Wildlife, Inc. v. City of Rancho Cucamonga, 175 Cal.App.4th 1306, 1339, 96 Cal.Rptr.3d 813 (2009) (affirming exclusion of self-described subjective statement: "I on behalf of Sage Council and Habitat Trust contemplated that the contract purpose of the Settlement Release Agreement (Exhibit 41) was to ...," where the witness "does not indicate that she expressed her asserted intention to anyone before or at the time of contracting" and "her prior language, acts and conduct evidence a contrary intention").

In contrast to these cases and others cited by Bayer, here Onyx's witnesses were present at the negotiations and contend their understanding of the meaning of contract terms is based on the course of those negotiations. See, e.g., Schenker Decl., Exh. 1 at 98 (excerpt of Renton depo. in which he states that he recalls talking about the definition of a collaboration compound with Bayer and that the "intent" to which he refers is based on "the assurances that Bayer gave us"); id., Exh. 26 at 5 (McCormick's declaration explaining the course of the negotiations in which he participated and his understanding of the contract based on those negotiations); id., Exh. 27 at 2-4 (Jones's declaration explaining the parties' notes and negotiations as to what would constitute a Collaboration Compound). This kind of extrinsic evidence is permitted, and indeed required, under California law. See Dept. of Indus. Relations v. UI Video Stores, Inc., 55 Cal.App.4th 1084, 1094, 64 Cal.Rptr.2d 457 (1997) ("[T]he circumstances surrounding the execution of the contract may be considered in determining the meaning of the language used therein.") (citing Cal.Code Civ. Proc., § 1860); Pac. Gas & Elec. Co. v. G.W. Thomas Drayage and Rigging Co., Inc., 69 Cal.2d 33, 39-40, 69 Cal.Rptr. 561, 442 P.2d 641 (1968) ("[R]ational interpretation requires at least a preliminary consideration of all credible evidence offered to prove the intention of the parties.").

Moreover, while Bayer is correct that courts have excluded evidence of the unexpressed intent of the parties, other courts applying California law have allowed witnesses to testify about their understanding of a contract when that understanding is not simply a private interpretation, but rather is founded in personal knowledge of the negotiations and the parties' expressed intent. See First Nat'l Mortg. Co. v. Fed. Realty Inv. Trust, 631 F.3d 1058, 1068 (9th Cir.2011) (witness testified as to "his understanding of the `subject only to approval' clause"); Mickey Bearman Co. v. John Morrell & Co., No. CV-00-05616 CAS (MCX), 2001 WL 36097432, at *3, 2001 U.S. Dist. LEXIS 26233, at *6-7 (C.D.Cal. Oct. 29, 2001) (attorney "who participated in the negotiations of the [contract], is entitled to testify as to what he, as a representative of [Defendant], thought the ambiguous terms meant."); ASP Properties Group v. Fard, Inc., 133 Cal.App.4th 1257, 1271, 35 Cal.Rptr.3d 343 (2005) ("When [Defendant's negotiator] was asked whether he understood at the time of negotiating the Amendment [that] Tenant would be required to improve the Premises, he answered, `Absolutely not.'"); Pacific Gas & Elec. Co. v. G.W. Thomas Drayage & Rigging Co., 69 Cal.2d 33, 39, 69 Cal.Rptr. 561, 442 P.2d 641 (1968) (offering, as example of circumstance warranting extrinsic evidence, situations in which "the parties' understanding of the words used may have differed from the judge's understanding" and requiring the court to consider evidence that would place it "in the same situation in which the parties found themselves at the time of contracting"); Wolf v. Superior Court, 114 Cal.App.4th 1343, 1359-60, 8 Cal.Rptr.3d 649 (2004) (finding triable issue of fact and lamenting the fact that "neither side presented any direct or objective evidence regarding the negotiating parties' understanding of the term `gross receipts' at the time the parties entered into the contract.").

The Court cannot discern any requirement that testimony must be supported by specific quotations of the words stated in negotiation. Rather, California case law merely stands for the proposition that a negotiator's testimony as to contract terms must be grounded in some foundation of personal knowledge as to the parties' expressed intent and understanding during the course of negotiations, rather than simply the witness's own subjective interpretation of the contract or intent as to what the contract should mean. See, e.g., Hoopes v. Dolan, 168 Cal.App.4th 146, 151, 85 Cal.Rptr.3d 337 (2008) ("The real estate agent said she conducted the lease negotiations with Hoopes, and that the issue of parking `never came up' during those negotiations."). While Bayer is certainly free to impeach the memory and credibility of these witnesses with their own deposition statements that they lacked specific recall of what was stated in the negotiations as to various contract terms, these weaknesses in their testimony are not sufficient to render them inadmissible.

Accordingly, Bayer's motion is DENIED as to this point, without prejudice to Bayer's objections at trial if certain portions of the witnesses' testimony are in fact based solely on their subjective, unexpressed intent.

2. Evidence of Bayer's Allegedly Improper Conduct Beyond CRC-KRAS & Breast AI

Bayer seeks to preclude Onyx from introducing testimony with regard to Bayer's other allegedly improper conduct in the course of developing Nexavar in indications beyond CRC-KRAS and Breast AI, as Onyx has not claimed compensatory damages with respect to that conduct. See Mot. at 1. Bayer argues that such evidence is irrelevant under Rule 402, prejudicial under Rule 403, and inadmissible character evidence under Rule 404(b).

At oral argument, Onyx agreed to drop four of the five indications and trials at issue — pulmonary arterial hypertension ("PAH"); gastrointestinal stromal tumor ("GIST"); thyroid cancer; and breast cancer in combination with the chemotherapy agent capecitabine ("Breast Cape"). Thus, the Court only considers the parties' arguments regarding 1st line colorectal cancer ("CRC").

With respect to relevance, Bayer contends that evidence of Bayer's alleged efforts to block Nexavar's development in CRC is irrelevant because Onyx does not claim any damages from this conduct, and the fact of damages is a necessary component of Onyx's claims for breach of contract and breach of fiduciary duty. See Mot. at 6. But as the Court pointed out at the hearing, the alleged conduct as to 1st line CRC, if proven to be part of a larger campaign to promote DAST and undermine Nexavar, is probative to Bayer's motive and conduct vis-a-vis the blocking of Nexavar trials for which damages are sought. As Onyx noted, both provisions of § 3.6 arguably import (at least the jury may so find) motive as an element of the breach claims. Section 3.6 makes Bayer's motive for blocking Nexavar relevant to whether it has breached the contract because if Bayer blocked Nexavar for legitimate business reasons and in good faith, there is no violation of § 3.6. These documents are also relevant not just to show Bayer's "motive" to breach, but as direct evidence of its alleged bad faith generally in violation of the implied covenant of good faith and fair dealing. See Universal Sales Corp. v. California Press Mfg. Co., 20 Cal.2d 751, 772, 128 P.2d 665 (1942) ("In every contract there is an implied covenant that neither party shall do anything which will have the effect of destroying or injuring the right of the other party to receive the fruits of the contract."). In addition, as discussed above, Bayer's argument against offering evidence of motive is, at the least, inapplicable to Onyx's tort-based claims.

Even assuming Bayer is correct that this conduct would be irrelevant for Onyx's damages claims, Bayer neglects to address Onyx's remaining claims, including a claim for declaratory relief in the form of "a declaration that Bayer cannot allow its products outside the Collaboration to prejudice the development of Nexavar." Joint Pretrial Statement, Docket No. 142, at 7. While Bayer seems to argue in reply that declaratory relief requires proof of damages as well, see Reply at 8, such an argument runs directly counter to the provisions of both the California and federal declaratory judgment statutes. See Cal. Code Civ. Pro. § 1060 ("[T]he court may make a binding declaration of these rights or duties, whether or not further relief is or could be claimed at the time.... The declaration may be had before there has been any breach of the obligation in respect to which said declaration is sought."); 28 U.S.C. § 2201(a) ("[A]ny court of the United States, upon the filing of an appropriate pleading, may declare the rights and other legal relations of any interested party seeking such declaration, whether or not further relief is or could be sought.").1

In addition, because Onyx will seek to show that Bayer's conduct is sufficiently outrageous to warrant punitive damages, evidence of the scope of Bayer's allegedly wrongful conduct is relevant to such a claim. Bayer points to the general and undisputed requirement that punitive damages must bear some relationship to compensatory damages as support for its position that evidence of Bayer's other alleged wrongdoing cannot support punitive damages. See Reply at 9 (citing O'Neil v. Spillane, 45 Cal.App.3d 147, 161, 119 Cal.Rptr. 245 (1975)); BMW of N. Am., Inc. v. Gore, 517 U.S. 559, 580, 116 S.Ct. 1589, 134 L.Ed.2d 809 (1996); Bains LLC v. Arco Prods. Co., 405 F.3d 764, 776-77 (9th Cir. 2005); Lew Wenzel & Co. of S. Cal., Inc. v. London Litho Supply Co., 563 F.2d 1367, 1368 (9th Cir.1977). However, these cases do not stand for the broad proposition that only evidence which is attached to a specific compensatory damages claim is relevant to a claim for punitive damages. Rather, these cases merely discuss the difficulty of awarding punitive damages when the plaintiff has suffered no compensable harm whatsoever, or when the amount of damages is out of proportion to the amount of compensatory damages. This does not answer the question of whether evidence for which the plaintiff does not claim damages may nonetheless inform a jury's determination of whether the defendant's conduct is worthy of punitive damages.

Indeed, on this question, BMW indicates that evidence that does not go directly to compensatory damages is nonetheless relevant and admissible. In BMW, the Supreme Court explicitly noted that conduct which could not form the basis of a punitive damages award — BMW's out-of-state conduct which was not unlawful in those states — was nonetheless relevant. See BMW, 517 U.S. at 574 n. 21, 116 S.Ct. 1589 ("Of course, the fact that the Alabama Supreme Court correctly concluded that it was error for the jury to use the number of sales in other States as a multiplier in computing the amount of its punitive sanction does not mean that evidence describing out-of-state transactions is irrelevant in a case of this kind. To the contrary, as we stated in TXO Production Corp. v. Alliance Resources Corp., 509 U.S. 443, 462, n. 28, 113 S.Ct. 2711, 125 L.Ed.2d 366 (1993), such evidence may be relevant to the determination of the degree of reprehensibility of the defendant's conduct."). The Court also considered evidence of potential harm. Id. at 575, 581-82, 116 S.Ct. 1589. Bayer can thus point to no case that suggests that each specific example of wrongdoing must be attached to a compensable damages claim in order to be relevant to its claim that Bayer breached its fiduciary duties and should pay punitive damages for its conduct.2

Accordingly, Bayer has failed to demonstrate that this evidence is irrelevant. See Fed.R.Evid. 401 (defining relevant evidence broadly to include any testimony "having any tendency to make the existence of any fact that is of consequence to the determination of the action more probable or less probable than it would be without the evidence").

Bayer also contends that this evidence would be prejudicial under Rule 403, and should be excluded on that basis. However, given its relevance as noted above, Bayer has failed to demonstrate that the prejudicial result from its introduction would substantially outweigh its probative value. Fed.R.Evid. 403. Bayer asserts that this evidence would distract and mislead the jury, and lead to a series of mini-trials. However, Onyx has alleviated most of these concerns by eliminating most of the indications at issue. In addition, the fact that Bayer will need to put on additional witnesses to explain and defend its conduct with respect to the same plaintiff, under the same contract, does not lead to the kind of prejudice or potential confusion that substantially outweighs the probative value of this evidence. Cf. Tennison v. Circus Circus Enterprises, Inc., 244 F.3d 684, 690 (9th Cir.2001) (in sexual harassment case, finding that the exclusion of evidence regarding complaints by other, non-plaintiff employees years prior to the conduct at issue in that action was not an abuse of discretion). The evidence is admissible under 403.

Finally, Bayer argues that this evidence is inadmissible character evidence under Rule 404(b), which prohibits "[e]vidence of other crimes, wrongs, or acts ... to prove the character of a person in order to show action in conformity therewith." The Court is not persuaded. As with its arguments discussed above, here Bayer ignores Onyx's non-damages claims, for which evidence of Bayer's alleged blocking of Nexavar in other indications is not "other crimes, wrongs, or acts," but rather is part of the same conduct Onyx challenges here and against which it seeks declaratory and punitive relief. Moreover, Rule 404(b) allows for such character evidence where it may show "proof of motive, opportunity, intent, preparation, plan, knowledge, identity, or absence of mistake or accident." While Bayer is correct that motive is not relevant in an action seeking contract damages, see Applied Equip. Corp. v. Litton Saudi Arabia Ltd., 7 Cal.4th 503, 516, 28 Cal.Rptr.2d 475, 869 P.2d 454 (1994), Onyx has asserted tort claims as well as contract claims in this action, and as explained at the hearing, Bayer's motive is relevant to a claim sounding in tort.3

Accordingly, the Court DENIES without prejudice Bayer's motion to exclude evidence of its alleged efforts to block Nexavar's development in trials other than Breast AI and CRC-KRAS.

3. Evidence Relating to Othello

Bayer seeks to exclude any documents related to Project Othello, its internal codename for discussions about its potential acquisition of Onyx in 2009. Mot. at 8. Bayer argues that these documents are irrelevant because Bayer never acquired Onyx, and prejudicial under Rule 403.

Given the content of these documents — which include admissions that Onyx may use to seek to rebut numerous positions Bayer is taking in this litigation — Bayer has failed to demonstrate that they are irrelevant or substantially more prejudicial than probative. As Onyx points out, see Opp. at 16-17, the fact that Bayer never acquired Onyx does not negate the relevance of its discussions to this litigation, as those discussions concerned the relationship and acknowledged potential conflicts between DAST and Nexavar, Bayer's obligations under the contract, and Bayer's ongoing relationship with Onyx. See, e.g., Trial Exh. 384 at -082-83, (indicating that the "[c]ommercial value of DAST is limited by Onyx partnership" and that DAST is in "direct competition with Nexavar" and has "very similar molecular structure"); Trial Exh. 397 (evaluating economic effects of developing DAST for certain indications instead of Nexavar); Trial Exh. 416 (discussing options for switching certain Nexavar trials to DAST); Trial Exh. 440 (discussing benefits of developing DAST over Nexavar in certain indications). This evidence is probative of Bayer's knowledge and thus its potential motives irrespective of the fact that it ultimately did not acquire Onyx.

Finally, as with the evidence discussed above in the second motion in limine, here Bayer has failed to demonstrate prejudice that would substantially outweigh the probative value of these documents as a whole. Again, Bayer assumes that this litigation solely involves a claim for breach of contract. See Reply at 14. Though the Court need not determine whether this evidence would be admissible if only contract claims were asserted, because bad faith and breach of fiduciary duty are at issue here, this evidence is sufficiently probative — notwithstanding its potential damaging effect on Bayer — to bring it outside the confines of 403.

Bayer's motion to exclude these documents is DENIED without prejudice to more tailored objections on a case-by-case basis.

4. Evidence of Damages

Bayer seeks to exclude any testimony from Onyx's damages expert, Iain Cockburn, as to Onyx's claimed damages from lost profits due to Bayer's alleged blocking of Nexavar's development in Breast AI and CRC-KRAS indications. Mot. at 11. Bayer argues that Cockburn's testimony cannot establish that Onyx suffered damages with reasonable certainty, as is required under California law. See Vestar Development II, LLC v. General Dynamics Corp., 249 F.3d 958, 961 (9th Cir.2001) ("It has long been settled in California that `the proof must establish with reasonable certainty and probability that damages will result in the future to the person wronged.'") (quoting Caminetti v. Manierre, 23 Cal.2d 94, 101, 142 P.2d 741, 745 (1943) (in bank)).

Bayer's arguments are nearly identical to those it raised in its motion for summary judgment, which Judge Patel denied. Indeed, much of Bayer's motion appears to have been cut and pasted from its earlier summary judgment motion. In her order, Judge Patel rejected Bayer's assertion that a 57% percent chance of FDA approval is insufficient to qualify as "reasonably certain." See Memorandum & Order, Docket No. 143, at 20. She found that "Onyx has raised at least an issue of fact as to the propriety of its requested damages." Id. Bayer has not requested leave to file a motion for reconsideration of that ruling. See Civ. L.R. 7-9.

Moreover, viewed independently, this Court agrees with Judge Patel's conclusion. Bayer argues that a 57-62% chance of FDA approval is insufficient as a matter of law to create a "reasonable certainty." Mot. at 13. In addition, Bayer contends that Onyx should not be permitted to present evidence of "risk-adjusted damages," which it claims demonstrate that Onyx's damages claims are speculative. See Mot. at 15-16. As Onyx has agreed at oral argument not to introduce any evidence of risk-adjusted damages, the Court considers only the reasonable certainty argument.

Bayer can point to no case, nor has Judge Patel or this Court uncovered such a case, in which California courts have mandated a percentage of certainty above 57% in order to constitute "reasonable certainty." See Memorandum & Order, Docket No. 143, at 20. Rather, most cases addressing reasonable certainty adhere to a qualitative approach, and the cases Bayer cites do not support the kind of wholesale rejection of evidence that Bayer requests from this Court. For example, as Judge Patel found, the principal case on which Bayer relies for its assertion that recovering damages for lost profits in pharmaceutical products is "exceedingly difficult," see AlphaMed Pharm. Corp. v. Arriva Pharm., Inc., 432 F.Supp.2d 1319 (S.D.Fla.2006), aff'd, 294 Fed.Appx. 501 (11th Cir.2008), is distinguishable on numerous grounds from the instant case. See Memorandum & Order at 19 (emphasizing that AlphaMed, unlike this case, involved a product that had never been tested, might have been illegal to distribute, and for which it was uncertain whether there was a sufficient research and development budget, among other differences). In another case on which Bayer relies, Matthews v. Atchison, Topeka & Santa Fe Railway Co., 54 Cal.App.2d 549, 560, 129 P.2d 435 (1942), the court was referring to a case in which the court reduced, rather than eliminated, damages to account for their lack of certainty.

Under California law, damages evidence found to be too speculative faced more uncertainty than is present in this case, in which Nexavar has already been approved for two cancer indications and the parties have experience successfully promoting its sale. See, e.g., Kids' Universe v. In2Labs, 95 Cal.App.4th 870, 887-888, 116 Cal.Rptr.2d 158 (2002) (finding expert testimony insufficient to demonstrate lost profits where a small toy store claimed that flood damage to the store caused by defendant led to $50 million in lost profits because Plaintiff's new website would have allowed it to compete in the Internet toy marketing business); Vestar Dev. II, LLC v. Gen. Dynamics Corp., 249 F.3d 958, 962 (9th Cir.2001) (finding lost profits claim too speculative for breach of agreement to negotiate where plaintiff sought "future profits that it hoped to earn from the shopping center it had planned to build on the parcel it was attempting to buy"); Eisenmayer v. Leonardt, 148 Cal. 596, 601, 84 P. 43 (1906) (affirming exclusion of testimony as to value of unissued stock for company never formed because there were "no facts stated — either real or hypothetical — as a basis for an intelligent opinion"); Greenwich S.F., LLC v. Wong, 190 Cal.App.4th 739, 766, 118 Cal.Rptr.3d 531 (2010) 1 (finding lost profits claim too speculative where the plaintiff assumed, rather than proved, the reasonable certainty of future predicate events upon which the damages depended); Fisher v. Hampton, 44 Cal.App.3d 741, 749, 118 Cal.Rptr. 811 (1975) (finding lost profits evidence too speculative where "there was no testimony that any oil could be recovered at a profit from the drilling of one well, and there was no testimony as to the extent of possible profits from the one initial well."); Boyer v. Wells, No. B205345, 2008 WL 3984342, at *8 (Cal.Ct.App. Aug. 29, 2008) ("Blaha's testimony that there are generally unforeseen rebuilding costs was too speculative to require the court to infer that there would be such costs in this case."). In contrast to these cases, courts allow for projections of lost profits for unestablished businesses when those projections are rooted in sound factual and statistical analysis, even though such testimony does not lend itself to absolute certainties with respect to future damages. See Kids' Universe v. In2Labs, 95 Cal.App.4th 870, 884, 116 Cal.Rptr.2d 158 (2002) ("[I]f the business is a new one or if it is a speculative one ..., damages may be established with reasonable certainty with the aid of expert testimony, economic and financial data, market surveys and analyses, business records of similar enterprises, and the like."); Parlour Enterprises, Inc. v. Kirin Group, Inc., 152 Cal.App.4th 281, 288, 61 Cal.Rptr.3d 243 (2007) ("[E]xpert testimony alone is a sufficient basis for an award of lost profits in the new business context when the expert opinion is supported by tangible evidence with a `substantial and sufficient factual basis' rather than by mere `speculation and hypothetical situations.'") (quoting Kids' Universe, 95 Cal. App.4th at 885, 116 Cal.Rptr.2d 158); 1 A & M Produce v. FMC Corp., 135 Cal.App.3d 473, 494, 186 Cal.Rptr. 114 (1982) (finding lost profits from destroyed tomato crop, which plaintiff had never grown before, proven to reasonable certainty where plaintiff "1 provide [d] evidence regarding the size of the crop and general market price for that type of tomato, the fact that he was an experienced farmer, the condition of the tomatoes pre-harvest, and the fact that there was no indication anything else would have ruined the crop had the machine functioned properly"); see also Lightning Lube, Inc. v. Witco Corp., 4 F.3d 1153, 1176 (3d Cir.1993) (finding lost profits from franchisees that never opened proven to reasonable certainty despite the fact that the witness "did not offer any documentary evidence comparing his operation to those of his competitors, did not discuss the market conditions for quick-lube centers generally, did not assess the impact of the stock market crash of 1987 on the likelihood of whether Lightning Lube would have gone public, and did not consider the impact of the 1990-91 recession on lube sales generally").

Those cases that do attach some mathematical component to the reasonable certainty analysis further support Onyx's view that a probability of greater than 50% is sufficient to create a "reasonable certainty." See Wagner v. Apex Marine Ship Mgmt. Corp., 83 Cal.App.4th 1444, 1452, 100 Cal.Rptr.2d 533 (2000) (discussing the need for a more flexible construction of the statute of limitations in latent disease cases because otherwise "most plaintiffs will be unable to prove that the likelihood of the future illness is "reasonably certain," i.e., greater than 50 percent, as courts generally require [for damages].") (quoting Wilson v. Johns-Manville Sales Corp., 684 F.2d 111, 119 (D.C.Cir.1982) ("Recovery of damages for speculative or conjectural future consequences is not permitted. To meet the "reasonably certain" standard, courts have generally required plaintiffs to prove that it is more likely than not (a greater than 50% chance) that the projected consequence will occur.")); see also Henderson v. Sheahan, 196 F.3d 839, 850 (7th Cir. 1999) ("Although the Illinois courts have yet to squarely define the meaning of "reasonable certainty," other jurisdictions have construed it to require a showing that it was more likely than not (i.e., greater than fifty percent probability) that the plaintiff would develop the serious injury in the future [to recover damages].") (citing cases from the Fifth and Sixth Circuits); Weeks Dredging & Contracting, Inc. v. B. Turecamo Towing Corp., 482 F.Supp. 1053, 1058 (E.D.N.Y.1980) (describing reasonably certain lost profits as "what profits more probably than not would have been earned had the incident not transpired"). Bayer contends that Wagner is inapposite because it concerns latent disease in a tort action. However, though not dispositive of the question, Wagner, like the instant case, involved analysis of a contingent event that affected the availability of future damages. In Wagner, it was latent asbestos-related disease, whereas here, it is FDA approval. Moreover, as Onyx points out, courts have treated tort and contract cases as analogous for purposes of establishing future damages. See Kids' Universe, 95 Cal.App.4th at 883, 116 Cal.Rptr.2d 158.

At the least, then, California law provides no indication that an estimated 57% likelihood of FDA approval cannot satisfy the reasonable certainty requirement. Moreover, as Judge Patel noted, Onyx has pointed out that 57% is a low bar in this case, as it estimates an 80% likelihood that at least one of the indications will succeed.4 See Memorandum & Order at 20 (citing Onyx Opp. to MSJ, Docket No. 96, at 24). Accordingly, the Court cannot conclude that Onyx's expert testimony is insufficient as a matter of law to demonstrate damages with reasonable certainty. Bayer's motion is denied.

III. WITNESSES

A witness or exhibit not listed in a party's pretrial conference statement may not be called or used without good cause. This rule does not apply to true rebuttal witnesses (other than experts). Defense witnesses are normally considered case-in-chief witnesses, not "rebuttal" witnesses.

The parties shall file their final witness lists by noon, September 30, 2011.

IV. EXPERT REPORTS

The parties shall lodge all expert reports, including their supplemental expert reports, with the Court no later than Wednesday, September 28, 2011.

V. EXHIBITS

Attached to this order as Exhibit A, the Court provides its rulings on Onyx's representative exhibits to which Bayer's objects. Attached as Exhibit B, the Court provides its rulings on Bayer's representative exhibits to which Onyx objects. At the pretrial conference herein, the Court explained the principles it employs in adjudicating relevance and admissibility. The parties are directed to meet and confer and resolve any remaining differences on objections. The parties shall submit a revised narrowed list of exhibits and any remaining objections by September 28, 2011.

VI. DEPOSITION DESIGNATIONS

The Court has considered the parties' representative deposition designations and objections, Docket No. 202. With respect to Bayer's designation number 5, Robert Jones 22:23-23:1, the Court reserves this question for trial as to whether Bayer has laid a sufficient foundation for the necessity of impeachment. With respect to Bayer's designation number 6, Robert Jones 113:25-114:22, the Court reserves the question for trial as it is keyed to Exhibit 1077, for which the Court has tentatively overruled Onyx's hearsay objection subject to a proper foundation at trial. See Exhibit B. With respect to all other representative deposition designations, the Court overrules the objections. As with the exhibits, the parties shall meet and confer and resolve objections. The parties shall submit a revised (narrowed) list by September 28, 2011.

VII. VOIR DIRE

Based on the parties' submissions and the Court's general practice, the Court intends to ask the following voir dire questions during jury selection. Counsel will be allowed a brief (20 minutes) follow-up voir dire after the Court's questioning.

1. Name 2. City of residence 3. Occupational Status 4. Organizations 5. Hobbies 6. Marital Status 7. Spouse's occupation 8. Children (including ages). 9. If a juror on another case 10. If ever a grand juror 11. If ever in the military. 12. Who is (or was) your employer? a. How long have you worked (or did you work) for that employer? 13. Please describe your educational background, including where you went to school, your major areas of study, and any degrees you have received. 14. The companies involved in this dispute are Bayer Corporation, Bayer AG, Bayer Healthcare LLC, Bayer Schering Pharma AG, Bayer HealthCare Pharmaceuticals, Inc., Bayer HealthCare Pharmaceuticals LLC (collectively referred to here as "Bayer") and Onyx Pharmaceuticals, Inc. (referred to here as "Onyx"). a. Other than in reference to the product Bayer Aspirin, have you ever heard of Bayer? b. Have you ever heard of Onyx? c. Have you, any member of your family, or any of your close friends ever worked for Bayer or Onyx or had any business relationship with Bayer or Onyx? Identify the person and explain. d. Have you or any member of your immediate family ever owned any stock, bond, or ever had any financial interest in Bayer or Onyx? 15. The law firms representing the parties involved in this dispute are Cooley LLP (formerly known as Cooley Godward and Cooley Godward Kronish), Morrison & Foerster LLP and Bartlit Beck Herman Palenchar & Scott LLP. Some of the specific attorneys involved are: From the law firm of Bartlit Beck Herman Palenchar & Scott LLP: Phil Beck Mark Levine Brian Swanson Scott McBride From the law firm of Morrison & Foerster: Alison Tucher From Bayer: Scott Meece From the law firm of Cooley LLP: Stephen C. Neal Martin S. Schenker Michelle S. Rhyu Benjamin Kleine From Onyx: Suzanne Shema 16. Do you have any college education, training, experience, or current or past employment in the following areas? (1) Pharmaceuticals (2) Medicine or healthcare (3) Biotechnology (4) Drug Discovery or Development (5) Chemistry including Medicinal Chemistry and Chemical Engineering (6) Biology 17. The products that will be discussed in this case are cancer-fighting drugs. (A) Have you, a family member or a close friend ever had cancer? (B) Have you, a family member or a close friend ever taken the medication Nexavar®? 18. Do you have any personal experience or training specifically involving the drafting or review of contracts, or dealing with a dispute over the terms of a contract, either in connection with your job or as part of your personal life? 19. Have you or an immediate family member ever started a business? 20. Do you have any personal knowledge of this case, or have you read about or heard it discussed, or have an opinion regarding it? 21. Have you or any member of your immediate family ever been a party to a lawsuit? Please describe. a. Were you the plaintiff or defendant? b. How was the case resolved? c. Will your experiences from that lawsuit impact your ability to decide this case in a fair and impartial way? 22. Are you or any member of your family an attorney or law student? 23. The following is a list of individuals who might appear as a witness in this case. Are you related to or personally acquainted with any of these individuals? 1. Lila Adnane 2. Shripad Bhagwat 3. Hans Bishop 4. Klaus Brandau 5. Gideon Bollag 6. Laura Brege 7. Iain Cockburn 8. N. Anthony Coles, Jr. 9. Jacques Dumas 10. Axel Eble 11. Henry (Hank) Fuchs 12. Mark Gelder 13. Greg Giotta 14. Arthur Higgins 15. Bob Jones 16. Juergen Lasowski 17. Christopher Lipinski 18. Nathalie Lokker 19. Ted Love 20. Tim Lowinger 21. John Lyons 22. Kemal Malik 23. Bob Mass 24. Frank McCormick 25. Joerg Moeller 26. Chris Peetz 27. Wolfgang Plischke 28. Len Post 29. Paolo Pucci 30. Mohan Rao 31. Hollings Renton 32. Bernd Riedl 33. Rob Rosen 34. Eric Rowinsky 35. Peter Sandor 36. Bill Scott 37. Scott Wilhelm 38. Todd Yancey 24. Do you have any other experience, opinion, or matter which you believe should be called to the Court's or the parties' attention that might have some bearing on your qualifications or ability to sit as a juror on this case, or which you think may prevent you from rendering a fair and impartial verdict based solely upon the evidence and the Judge's instructions as to the law? 25. Have you ever been involved in a serious business dispute? Briefly describe the nature of the dispute and how it was resolved.

VIII. JURY INSTRUCTIONS & VERDICT FORM

The Court shall address the verdict form at a subsequent date.

Regarding instructions, as the Court noted at the pretrial conference, the parties are directed to meet and confer and try to reach an agreement on the instructions. The parties shall file with the Court no later than noon Friday, September 23, 2011, a set of agreed upon instructions and the parties' respective positions and proposed language where they disagree.

In addition to the above, the parties shall provide the Court with any stipulated facts to be read to the jury, to be filed on September 23, 2011, along with the jury instructions.

IT IS SO ORDERED.

PRETRIAL CONFERENCE ORDER EXHIBIT A — ONYX EXHIBITS WITH BAYER OBJECTIONS

#    Exh.   Description              Onyx Statement of                Bayer            Onyx           Court's
      #                                  Relevance                  Objection       Response to       Ruling*
                                                                                     Objections

1    185    Nexavar                  This video, prepared           802; 805        Bayer's           Overruled
            Launch                   jointly by Onyx and                            statements are
            Video 004                Bayer, contains                                party-opponent
            (native                  statements by Onyx                             admissions
            video)                   and Bayer scientists                           and are
                                     and physicians                                 therefore not
                                     regarding the discovery                        hearsay.
                                     and development of                             Bayer
                                     Nexavar, including                             endorsed the
                                     statements on technical                        statements by
                                     issues relating to the                         Onyx and
                                     "recognition" that                             third parties,
                                     DAST met the Exhibit                           which were
                                     D standard (which is                           also made in
                                     relevant to the                                the regular
                                     Collaboration                                  course of
                                     Compound dispute)                              business.
                                     and concerning the
                                     adverse effect profile
                                     of Nexavar (which is
                                     relevant to Onyx's
                                     claims under § 3.6 of
                                     the Collaboration
                                     Agreement).

2    219    Email from               This exhibit                   402; 403;       The document      Overruled
            P. Pucci to              demonstrates Bayer's           subject of      is relevant
            A. Busch et              competing interests in         MIL             and probative
            al. re: Re:              Nexavar and DAST in                            to Onyx's §
            Sorafenib —             the context of the                             3.6 claim.
            Relief For               development of                                 Any risk of
            Many                     Nexavar for treatment                          prejudice,
            Sufferers of             of pulmonary                                   confusion, or
            Pulmonary                hypertension (also                             waste of time
            Hypertension             known as "PAH") (See                           does not
                                     also Onyx's                                    "substantially
                                     Opposition to Bayer's                          outweigh" the
                                     Motion in Limine.)                             probative
                                                                                    value of the
                                                                                    document.

3    315    Nexavar in               This exhibit reveals           402; 403;       The document      Overruled
            PAH - Recommended        Bayer's concern with           subject of      is relevant
            Path                     allowing Nexavar               MIL             and probative
            Forward                  development in PAH                             to Onyx's §
            Presentation             due to the risk of                             3.6 claim.
                                     creating a competitor                          Any risk of
                                     to DAST. (See also                             prejudice,
                                     Onyx's Opposition to                           confusion, or
                                     Bayer's Motion in                              waste of time
                                     Limine.)                                       does not
                                                                                    "substantially
                                                                                    outweigh" the
                                                                                    probative
                                                                                    value of the
                                                                                    document.

4    365    Email from               This internal Bayer            402; 403        The document      Overruled
            R. Rosen to              document shows that                            is relevant
            H. Bishop                Bayer oncology                                 and probative
            et al. re: EC            personnel initially were                       to Onyx's §
            Alignment-Please         prepared to support the                        3.6 claim.
            Read                     development of                                 Any risk of
                                     Nexavar in 2nd line                            prejudice,
                                     CRC-KRAS. After                                confusion, or
                                     Bayer decided to                               waste of time
                                     develop DAST in                                does not
                                     CRC, and performed                             "substantially
                                     calculations showing                           outweigh" the
                                     that it would realize                          probative
                                     greater profits from                           value of the
                                     developing DAST in                             document.
                                     CRC, Bayer refused to
                                     authorize the Nexavar
                                     trial in CRC KRAS.

5    384    Oncology                 As explained in detail         402; 403;       The document      Overruled
            Strategy - BoM           in Onyx's opposition to        subject of      is relevant
            Presentation             Bayer's Motion in              MIL             and probative
                                     Limine (at 11-15), this                        to Onyx's §
                                     exhibit contains                               3.6 claim.
                                     numerous highly                                Any risk of
                                     relevant facts that                            prejudice,
                                     contradict Bayer                               confusion, or
                                     positions. (See also                           waste of time
                                     Onyx's Opposition to                           does not
                                     Bayer's Motion in                              "substantially
                                     Limine at 11-17.)                              outweigh" the
                                                                                    probative
                                                                                    value of the
                                                                                    document.

6    397    Spreadsheet              This exhibit contains          402; 403;       The document      Overruled
            Model re:                Bayer's economic               subject of      is relevant
            General                  modeling of various            MIL             and probative
            Project                  development options                            to Onyx's §
            Information              for DAST. It reveals,                          3.6 claim.
            for DAST                 among other things,                            Any risk of
                                     that DAST and                                  prejudice,
                                     Nexavar would                                  confusion, or
                                     "cannibalize" one                              waste of time
                                     another if both drugs                          does not
                                     were developed in the                          "substantially
                                     same indications and                           outweigh" the
                                     that Bayer would                               probative
                                     potentially earn                               value of the
                                     hundreds of millions of                        document.
                                     dollars of additional
                                     profits if it developed
                                     DAST, rather than
                                     Nexavar, as a treatment
                                     for CRC. (See also
                                     Onyx's Opposition to
                                     Bayer's Motion in
                                     Limine at 11-17.)

7    416    Email from               This internal document         402; 403;       The document      Overruled
            P. Sandor to             circulated among               subject of      is relevant
            R. Rosen et              Bayer's senior                 MIL             and probative
            al. re:                  oncology team reveals                          to Onyx's §
            DAST vs.                 that Bayer reached a                           3.6 claim.
            NXV                      decision to develop                            Any risk of
                                     DAST extensively by                            prejudice,
                                     mid - January, less than                       confusion, or
                                     one week before Onyx                           waste of time
                                     proposed its Phase 3                           does not
                                     trials of Nexavar in                           "substantially
                                     CRC KRAS and Breast                            outweigh" the
                                     AI. The email chain                            probative
                                     also contains a                                value of the
                                     discussion of Bayer's                          document.
                                     "switching strategy,"
                                     which is highly
                                     relevant for the reasons
                                     discussed in Onyx's
                                     Opposition to Bayer's
                                     Motion in Limine.
                                     (See also Onyx's
                                     Opposition to Bayer's
                                     Motion in Limine at
                                     17-19.)

8    439    Email from               This exhibit contains          602             This is an        Overruled
            L. Adnane                statements from Bayer                          internal email
            to B. Lu et              scientists concerning                          between
            al. re:                  their recognition that                         Bayer
            DAST                     Nexavar and DAST                               personnel,
            MOA                      inhibit cancer through                         produced
                                     the same mechanism of                          from Bayer's
                                     action, and evidences                          files. Rule
                                     Bayer's knowledge                              602 does not
                                     that DAST would                                preclude the
                                     compete directly with                          admission
                                     Nexavar.                                       into evidence
                                                                                    of this
                                                                                    internal Bayer
                                                                                    document.

9    440    DAST in                  This exhibit presents          402; 403;       The document      Overruled
            Development              Bayer's economic               602;            is relevant
            Scenarios-Assumptions    modeling showing that          subject of      and probative
            and                      developing DAST in             MIL             to Onyx's §
            Results                  competition to Nexavar                         3.6 claim.
            Presentation             was far more profitable                        Any risk of
                                     than limiting DAST to                          prejudice,
                                     indications in which                           confusion, or
                                     Nexavar was not being                          waste of time
                                     developed. It also                             does not
                                     establishes that an even                       "substantially
                                     more profitable option                         outweigh" the
                                     for Bayer than                                 probative
                                     developing DAST and                            value of the
                                     Nexavar in competing                           document.
                                     indications would be
                                     for Bayer to block
                                     Nexavar development
                                     in any indication in
                                     which Bayer planned
                                     to develop DAST.
                                     (See also Onyx's
                                     Opposition to Bayer's
                                     Motion in Limine at
                                     11-19.)

10   497    Email from               This exhibit shows that        802             Qualifies for     Overruled
            T. Coles to              Onyx asked Bayer                               business
            A. Fibig et              about the structure of                         records
            al. re:                  DAST in March 2009.                            exception.
            DAST                     In response, Bayer
                                     disclosed the structure
                                     to Onyx. The timing of
                                     this disclosure is
                                     relevant to Bayer's
                                     statute of limitations
                                     and laches defenses.

11   503    Email from               This exhibit                   402; 802;       The document      Overruled
            B. Flannelly             demonstrates that              805;            is relevant
            to T. Coles              Bayer blocked                  subject of      and probative
            et al. re:               Nexavar's                      MIL             to Onyx's §
            CRC 1st                  development as a first                         3.6 claim.
            Line                     line treatment for                             Any risk of
                                     colorectal cancer.                             prejudice,
                                     Onyx explained the                             confusion, or
                                     relevance of Bayer's                           waste of time
                                     strong arm tactics                             does not
                                     disclosed in its                               "substantially
                                     document in its                                outweigh" the
                                     opposition to Bayer's                          probative
                                     Motion in Limine.                              value of the
                                     (See Onyx's                                    document.
                                     Opposition to Bayer's                          Qualifies for
                                     Motion in Limine at 8-9.)                      business
                                                                                    records
                                                                                    exception to
                                                                                    hearsay. In
                                                                                    addition,
                                                                                    Bayer's
                                                                                    statements are
                                                                                    party-opponent
                                                                                    admissions.

12   506    Email from               This exhibit, an               402; 403;       The document      Overruled
            H. Bishop                internal Bayer e-mail,         subject of      is relevant
            to R. Rosen              describes Bayer's              MIL             and probative
            et al. re:               opposition to Onyx's                           to Onyx's §
            CRC 1st                  proposal to pursue a                           3.6 claim.
            Line                     clinical trial of                              Any risk of
                                     Nexavar in CRC.                                prejudice,
                                     Among other things,                            confusion, or
                                     the e-mail includes the                        waste of time
                                     statement that "we also                        does not
                                     need to keep in mind                           "substantially
                                     that it [i.e., CRC] is                         outweigh" the
                                     most likely a place                            probative
                                     where we would put                             value of the
                                     DAST which make                                document.
                                     [sic] the issue more
                                     convoluted." The
                                     relevance of this
                                     evidence is discussed
                                     in greater length in
                                     Onyx's opposition to
                                     Bayer's Motion in
                                     Limine (See Onyx's
                                     Opposition to Bayer's
                                     Motion in Limine at 8-9.)

13   509    Email from               This exhibit                   402; 403;       The document      Overruled
            A. Wagner                demonstratives Bayer's         subject of      is relevant
            to B. Lu et              desire to keep secret its      MIL             and probative
            al. re: ITOG             competing interests in                         to Onyx's §
                                     DAST as of March                               3.6 claim.
                                     2009 and to steer key                          Any risk of
                                     opinion leaders to                             prejudice,
                                     DAST, and away from                            confusion, or
                                     Nexavar.                                       waste of time
                                                                                    does not
                                                                                    "substantially
                                                                                    outweigh" the
                                                                                    probative
                                                                                    value of the
                                                                                    document.

14   539    Email from               This exhibits                  402; 403;       Onyx's            Overruled
            J. Lasowski              underscores the                802;            proposal to
            to T. Coles              different approaches to        subject of      Bayer to
            et al. re:               the collaboration              MIL             pursue a joint
            Ardea                    exhibited by the two                           business
                                     parties and the role of                        transaction is
                                     DAST in coloring                               a business
                                     Bayer's conduct                                record and
                                     towards Onyx. In this                          not hearsay.
                                     exhibit, Onyx invited                          Moreover, the
                                     Bayer to join Onyx in                          exhibit was
                                     evaluating a possible                          offered to
                                     joint transaction                              demonstrate
                                     involving Ardea, a                             that Onyx
                                     company developing a                           made its
                                     drug that held promise                         proposal.
                                     as a combination
                                     partner for Nexavar.
                                     Bayer ignored Onyx's
                                     invitation, pursued
                                     secret discussions with
                                     Ardea, culminating in
                                     an exclusive license
                                     agreement, and is now
                                     planning combination
                                     trials with Ardea's
                                     drug and DAST.

15   540    Email from               This exhibit contains          402; 403;       The document      Overruled
            H. Bishop                Onyx's reaction to the         subject of      is relevant
            to A.                    announcement that              MIL             and probative
            Higgins, cc:             Bayer had entered into                         to Onyx's §
            A. Fibig re:             an agreement with                              3.6 claim.
            Onyx/Tony                Ardea that excluded                            Any risk of
            Coles                    Onyx, followed by an                           prejudice,
                                     internal Bayer e-mail                          confusion, or
                                     admitting that Bayer's                         waste of time
                                     "aspirations for this                          does not
                                     molecule go beyond                             "substantially
                                     Nexavar."                                      outweigh" the
                                                                                    probative
                                                                                    value of the
                                                                                    document.

16   838    Email from               This exhibit contains          402; 403;       Not hearsay       Overruled
            B. Flannelly             Bayer's notification to        802             since offered
            to J.                    Onyx, made six months                          to show
            Lasowski et              after Onyx's original                          Bayer email
            al. re: Bayer            invitation to pursue a                         received by
            and Ardea                joint transaction, that                        Onyx.
            BioSciences              Bayer had entered into
            Announcement             an exclusive license
                                     agreement with Ardea,
                                     along with a cover note
                                     from the recipient to
                                     Onyx management
                                     notifying them of
                                     Bayer's disclosure.

17   867    Minutes of               This document                  402; 403;       The document      Overruled
            the Bayer                provides the minutes of        Subject of      is relevant
            Schering                 the meeting at which           MIL             and probative
            Pharma AG                the Oncology Strategy                          to Onyx's §
            Board of                 Project slides were                            Any risk of
            Management               presented to Bayer                             3.6 claim.
            Meeting                  management and                                 prejudice,
            (BoM)                    provides the best                              confusion, or
            01/09                    evidence of the date on                        waste of time
                                     which the meeting took                         does not
                                     place. It is therefore                         "substantially
                                     relevant and probative                         outweigh" the
                                     to Onyx's claims of                            probative
                                     breach of § 3.6 of the                         value of the
                                     Collaboration                                  document.
                                     Agreement.

* All objections that are overruled are without prejudice as to lack of foundation (e.g., business
records). Evidence to which objections are overruled is still subject to foundation requirements.

PRETRIAL CONFERENCE ORDER EXHIBIT B — BAYER EXHIBITS WITH ONYX
OBJECTIONS

#     Exh.     Description                Bayer               Onyx        Bayer Response to        Ruling*
       #                               Statement of         Objection     Onyx's Objection
                                        Relevance

1     Exh.     Onyx                    Shows Onyx's         501, 802,     Privilege log is by      Sustained
      1048     Privilege               knowledge of         Cal Code      definition not
               Log                     DAST and its         Evid 913      privileged, it's a
                                       actions in                         801(d)(2) party
                                       response to that                   admission, and
                                       knowledge                          California evidence
                                                                          rules don't apply to
                                                                          federal court
                                                                          proceeding. Even if
                                                                          it did, not seeking
                                                                          any inference about
                                                                          the privileged
                                                                          actions, merely the
                                                                          existence of the
                                                                          communications
                                                                          about the subjects
                                                                          listed.

2     Exh.     1053                    Data from            802           It is an 803(6)          Overruled
               Spreadsheet             Bayer's files                      business record.
               R&D project             showing how                        This is an output of
               costs                   much Bayer                         specific financial
                                       spent 2007-2011                    data kept in the
                                       for                                ordinary course of
                                       development of                     an electronic
                                       DAST.                              business by Bayer in
                                                                          database.

3     Exh.      Onyx Q4                Transcript of        802           It is an 801(d)(2)       Overruled
      1070      2010                   Onyx's                             party admission.
                Earnings               statements
                Conf call              shows its
                                       characterization
                                       of the
                                       development of
                                       Nexavar as well
                                       as its other
                                       pipeline drugs.

4     Exh.     4/26/06 Post            Onyx internal        403           Onyx improperly          Overruled
      1071     email to                email shows its                    claims prejudice for
               Renton re:              position                           a document based
               Other                   regarding both                     on the fact that it
               indications             parties potential                  helps prove Bayer's
                                       interest in                        case. There is no
                                       developing                         prejudice evident
                                       drugs in                           from Onyx's Senior
                                       indications that                   VP of R&D
                                       might also be                      discussing his
                                       available for                      understanding of
                                       Nexavar, and                       how Bayer and
                                       how Bayer and                      Onyx's interests in
                                       Onyx's                             development for
                                       interests might                    Nexavar and other
                                       diverge.                           compounds might
                                                                          align.

5     Exh.     1/25-26/94              Contemporaneous      802           It is an 803(6)          Overruled
      1077     meeting                 memo that                          business record, it
               minutes                 documents                          contains 801(d)(2)
               between                 negotiations of                    party admissions of
               Onyx and                Collaboration                      Onyx during
               Bayer/Miles             Agreement                          negotiations, and the
                                                                          Bayer statements
                                                                          contained within
                                                                          provide necessary
                                                                          context for Onyx's
                                                                          admissions.
                                                                          Deposition
                                                                          testimony from
                                                                          Klaus Brandau
                                                                          supports that the
                                                                          author of the
                                                                          minutes had the
                                                                          responsibility for
                                                                          taking meeting notes
                                                                          and subsequently
                                                                          turning them into
                                                                          minutes.

6     Exh.     4/3/09                  Bayer email to       802           It is an 803(6)          Overruled
      1102     Bishop email            Onyx reflects                      business record and
               to Coles re:            consistent                         it contains both
               DAST                    belief that                        801(d)(2) Onyx
                                       DAST is not a                      party admissions
                                       collaboration                      and also context for
                                       compound.                          understanding those
                                                                          admissions.

7     Exh.     11/25/09                Letter from          402           Section 3.6 is a         Sustained
      1121     Rhyu letter             Onyx's lawyer                      disputed section in
               to Swanson              containing                         this case and
               re:                     Onyx's position                    evidence relating to
               Discovery               regarding its                      Onyx's
               Issues                  interpretation of                  interpretation of that
                                       section 3.6                        section is probative
                                                                          of that dispute.

8     Exh.     9/21/05                 It relates to        402, 403,     It is an 801(d)(2)       Sustained
      1127     Schenker                Bayer/Onyx           802           party admission.
               email string            negotiations of                    Any potential
               to Quigley              an amendment                       prejudice from
               re: Revised             to                                 redactions can be
               Draft Co-Promotion      Collaboration                      cured by Court's
               Agreement               Agreement.                         instruction to jury
                                                                          on privilege, if
                                                                          necessary.

9     Exh.     11/12/93                This documents       802           It is an 803(6)          Overruled
      1137     Bayer/Onyx              negotiations of                    business record, it
               meeting                 Collaboration                      contains 801(d)(2)
               minutes                 Agreement.                         party admissions of
                                                                          Onyx during
                                                                          negotiations, and the
                                                                          Bayer statements
                                                                          contained within
                                                                          provide necessary
                                                                          context for Onyx's
                                                                          admissions.
                                                                          Deposition
                                                                          testimony from
                                                                          Klaus Brandau
                                                                          supports that the
                                                                          author of the
                                                                          minutes had the
                                                                          responsibility for
                                                                          taking meeting notes
                                                                          and subsequently
                                                                          turning them into
                                                                          minutes.

10    Exh.     7/29/93                 It reflects Onyx     402, 403      There's no evident       Sustained
      1151     Onyx BOD                update to its                      prejudice associated
               meeting                 board of                           with Board Minutes,
               minutes                 directors on                       and does not
                                       status of                          substantially
                                       negotiation of                     outweigh probative
                                       the                                value of evidence
                                       Collaboration                      that Onyx's Board
                                       Agreement in                       of Directors
                                       July 1993.                         discussed
                                                                          negotiations in this
                                                                          time period.

11    Exh.     3/9/11 Turck            Reflects             802           It is an 803(6)          Overruled
      1162     email to                Bayer's notice                     business record of
               Brege on                to Onyx that it                    Bayer/Onyx
               going                   would agree to                     dealings, and it is
               forward with            proceed with                       necessary context
               AI                      modified Breast                    for Onyx 801(d)(2)
                                       AI study.                          party admissions
                                                                          regarding the Breast
                                                                          AI study.

12    Exh.     9/6/01                  Reflects Bayer       802           It is an 803(6)          Overruled
      1193     Shimei                  and Onyx                           business record of
               fax/letter to           dealing with                       Bayer/Onyx
               Giotta re:              prior disputes                     dealings in the
               Pho Kinase              over whether                       Collaboration.
               Inhibitor Bay           compounds are
               60-8829                 Collaboration
                                       Compounds,
                                       showing
                                       Onyx's
                                       awareness of
                                       the issue yet
                                       failure to take
                                       action in 2005.
                                       This is relevant
                                       to the laches
                                       defense, as well
                                       as contract
                                       interpretation.

13    Exh.     12/8/05                 Reflects Bayer       802           It is an 803(6)          Overruled
      1198     conference              public                             business record. It
               call                    statements                         may also not be
               transcript re:          about DAST                         used for the truth of
               Bayer R&D               development,                       the matter asserted
               Investor Day            which Onyx                         (DAST development
               2005                    representatives                    plans), but rather as
                                       admitted that                      evidence that Bayer
                                       they heard.                        made the statements
                                       Onyx's lack of                     contained within the
                                       action                             document about
                                       following this                     DAST, and that
                                       call is relevant                   Onyx witnesses to
                                       to the laches                      the conference call
                                       defense as well                    heard those
                                       as contract                        statements regarding
                                       interpretation.                    DAST.

14    Exh.     3/5/08                  Reflects Onyx's      802           It is an 803(6)          Sustained
      1213     Southerton              development of                     business record of
               email to                non-Nexavar                        Pfizer/Onyx
               Giotta re:              drugs for                          dealings on their
               status of               treatment of                       joint compound
               PD332991                cancer,                            under development.
               clinical                including
               development             indications that
                                       it is also
                                       interested in
                                       developing
                                       Nexavar

15    Exh.     11/13/09                This is the letter   402           This is the letter to    Sustained
      1422     Swanson                 to which Exh                       which Exh 1121 is
               letter to               1121 is                            responding, and
               Rhyu                    responding, and                    relates to Onyx's
                                       relates to                         interpretation of
                                       Onyx's                             section 3.6 of the
                                       interpretation of                  Collaboration
                                       section 3.6 of                     Agreement. It is
                                       the                                necessary for
                                       Collaboration                      context and
                                       Agreement. It                      understanding of
                                       is necessary for                   Onyx's statements
                                       context and                        in Exh. 1121.
                                       understanding
                                       of Onyx's
                                       statements in
                                       Exh. 1121.

16    Exh.     8/12/09                 Reflects Bayer       802           It is an 803(6)          Sustained
      1549     Bishop email            internal notice                    business record.
               to Rosen et             regarding
               al. re: DAST            principles for
               and Nexavar             DAST
               testing                 development
               (guiding
               principles for
               development)

17    Exh.     3/28/01                 Reflects             802           Contains 801(d)(2)       Overruled
      1592     Brocks email            discussion of                      party admissions
               string to               Nexavar                            and context for
               Busse re:               development                        those admissions.
               Onyx                    and Onyx's                         Also functions as an
               nonoptioning            plans regarding                    803(6) business
               of co-development       that                               record.
                                       development.

18    Exh.     1/20/11                 Reflects             802           It is an 803(6)          Overruled
      1674     presentation:           updates and                        business record of
               Frontline               discussions of                     Bayer/Onyx
               Aromatase               Nexavar                            development
               Inhibitor               development in                     discussions, like the
               Breast                  the disputed AI                    many other
               Cancer                  indication.                        examples of similar
               Business                                                   powerpoints in the
               Case                                                       exhibits for which
               Overview                                                   no objection was
                                                                          leveled.

19    Exh.     9/26/07                 Reflects             403, 802      Contains 801(d)(2)       Sustained
      1708     Malik email             discussions of                     party admissions of
               string to               bringing DAST                      Onyx and context
               Moeller re:             into                               for those
               PAH                     Collaboration                      admissions.
               sorafenib               with Onyx.                         Onyx improperly
                                                                          claims prejudice for
                                                                          a document based
                                                                          on the fact that it
                                                                          helps prove Bayer's
                                                                          case.

20    Exh.     Urea                    Spreadsheet of       802           It is an 803(6)          Overruled
      1776     Spreadsheet.            data from                          business record.
               xls & ".DB"             Bayer's files of                   This is an output of
               file                    the relevant                       specific chemical
                                       compositions of                    data kept in the
                                       matter made                        ordinary course of
                                       and tested by                      business by Bayer in
                                       Bayer during                       an electronic
                                       the                                database that tracks
                                       Collaboration                      all chemistry and
                                       and the RKI2                       biology work done
                                       project,                           at Bayer.
                                       including dates
                                       of synthesis.

21    Exh.     1/28/10                 Reflects issues      802           It is an 803(6)          Overruled
      1778     Breast AI               of Nexavar's                       business record of
               PPT for EC              development in                     Nexavar
                                       the disputed AI                    development,
                                       indication.                        prepared for the
                                                                          joint Executive
                                                                          Committee. It also
                                                                          contains 801(d)(2)
                                                                          Onyx party
                                                                          admissions and
                                                                          context for those
                                                                          admissions.

22    Exh.     Spreadsheet             Data showing         802, 901      It is an 803(6)          Overruled
      1796     how much                                                   business record.
               Bayer spent                                                This is an output of
               2007-2011 for                                              specific financial
               development of                                             data kept in the
               DAST,                                                      ordinary course of
               Nexavar, and                                               business by Bayer in
               all other                                                  an electronic
               oncology drugs.                                            database. Onyx has
                                                                          no reasonable belief
                                                                          that the document is
                                                                          not authentic given
                                                                          that its format and
                                                                          content is consistent
                                                                          with and
                                                                          corroborated by
                                                                          other similar
                                                                          business records like
                                                                          Exh. 1053 and Exh.
                                                                          1089 that are
                                                                          outputs from the
                                                                          same database.

23    Exh.     4/14/11 Joint           Reflects             802           It is an 803(6)          Overruled
      1826     Development             discussions and                    business record of
               Committee               presentations                      Nexavar
               meeting                 on Nexavar                         development.
               Agenda and              development at
               slides                  JDC (both
                                       Bayer and
                                       Onyx have
                                       members),
                                       including in
                                       indications in
                                       dispute in this
                                       case

24    Exh.     1/19/05                 Relates to           402, 403      It is an 803(6)          Overruled
      1833     presentation            Nexavar                            business record.
               re: Sorafenib           development,                       There's no apparent
               Full                    including issues                   prejudice in the
               Potential               in disputed                        document and it
               "Back of the            indications.                       doesn't outweigh its
               Envelope"                                                  probative value
               Assessment                                                 regarding
                                                                          evaluations of
                                                                          potential Nexavar
                                                                          development. Onyx
                                                                          improperly claims
                                                                          prejudice for a
                                                                          document based on
                                                                          the fact that it helps
                                                                          prove Bayer's case.

25    Exh.     6/30/08 Post            Internal Onyx        403           There is no         Overruled
      1834     email to                email shows                        prejudice associated
               Fuchs re:               Onyx's                             with Onyx's
               ACT Biotech             knowledge                          knowledge of
                                       regarding                          DAST. Onyx
                                       DAST, relevant                     improperly claims
                                       to the laches                      prejudice for a
                                       defense as well                    document based on
                                       as contract                        the fact that it helps
                                       interpretation.                    prove Bayer's case.
                                                                          Any potential
                                                                          prejudice from
                                                                          redactions can be
                                                                          cured by
                                                                          instructions from the
                                                                          Court.

* All objections that are overruled are without prejudice as to lack of foundation (e.g., business

GUIDELINES FOR TRIAL IN CIVIL CASES (JURY AND BENCH)

PRETRIAL ARRANGEMENTS

1. Should a daily transcript and/or real-time reporting be desired, the parties shall make arrangements with the Supervisor of the Court Reporting Services at (415) 522-2079, at least ten calendar days prior to the trial date.

2. During trial, parties may wish to use, e.g., overhead projectors, laserdisk/computer graphics, poster blow-ups, models, or specimens of devices. The United States Marshal requires a court order to allow equipment into the Courthouse. Parties should be prepared to fix any equipment, if necessary.

SCHEDULING

1. Trial will normally be conducted from 8:30 a.m. to 2:00 p.m. (or slightly longer to finish a witness), with one 15-minute break and one 40-minute lunch break. Parties must arrive by 8:00 a.m. or, in a jury trial, earlier as needed for any matters to be heard out of the presence of the jury. The jury will be called at 8:30 a.m. The trial week is Monday through Thursday, excluding holidays. Fridays are dark.

JURY SELECTION

1. In civil jury cases, there are no alternate jurors, and the jury is typically selected as follows. At the outset, 18 potential jurors are called and seated in the jury box and front courtroom bench in the order their names are drawn from the drum. This placement will determine their order in the selection process. The Court will first conduct its voir dire of the entire panel (not just the seated 18) to determine hardships. Jurors excused from the seated 18 will be replaced from those drawn from the panel. The Court will then voir dire the seated 18 for cause. Afterwards, the parties will be allowed a brief follow-up voir dire (15 minutes). Once all voir dire is completed, the Court will address all challenges for cause and excuse those potential jurors who have been successfully challenged. After a short recess, each side may exercise its allotment of peremptory challenges. The plaintiff has the first challenge, the defendant the next two, the plaintiff the next two, and so forth. The default number of peremptory challenges per party or side is three. Any party that passes will be deemed to have used a challenge. The eight (or such other size as will constitute the jury) surviving the challenge process with the lowest numbers become the final jury. Once the jury selection is completed, the jurors' names will be read again, and they will be seated in the jury box and sworn in. The Court may alter the above procedure in its discretion.

2. Jurors may take notes. Note pads will be distributed at the beginning of each trial. The pads will remain in the jury room at the end of each day. Jurors will be instructed on the use of notes both in the preliminary and final jury instructions.

TIME LIMITS

1. Ordinarily, the Court shall set fixed time limits for the presentation of evidence by each side at the final pretrial conference. The time limit includes all examination time (whether direct, cross, re-direct, or re-cross) for each witness regardless of which party called the witness. Opening and closing time limits shall be separately considered.

OPENING STATEMENTS

1. Each side may be subject to a predetermined time limit for its opening statement.

2. Parties must cooperate and meet and confer to exchange any visuals, graphics, or exhibits to be used in the opening statements, allowing for time to work out objections and any reasonable revisions one court day in advance of trial.

3. In a jury case, parties should be prepared to give opening statements as soon as the jury is sworn.

WITNESSES

1. At the close of each trial day (at 2:00 p.m.), parties shall exchange a list of witnesses for the next full court day and the exhibits that will be used on direct and cross-examination (other than for impeachment of an adverse witness). By 4:00 p.m. that same day, opposing parties shall provide any objections to such exhibits and further shall provide a list of all exhibits to be used with the same witnesses on cross-examination (other than for impeachment). The Court will address objections before 8:30 a.m. on the following day. The first notice of objection shall be provided one court day prior to the first day of trial. All notices should be provided in writing and filed with the Court, and a courtesy copy should be given to chambers immediately.

2. Parties should always have their next witness ready and in the Courthouse. Failure to have the next witness ready may constitute resting.

3. Parties are expected to cooperate with each other in the scheduling and production of witnesses. Witnesses may be taken out of order if necessary. Every effort shall be made to avoid calling a witness twice (as an adverse witness and later as a party's witness).

4. If a witness is testifying at the time of a recess or adjournment and has not been excused, the witness shall be seated back on the stand when court reconvenes. If a new witness is to be called immediately following recess or adjournment, the witness should be seated in the front row, ready to be sworn.

5. Immediately before each new witness takes the stand, counsel calling the witness shall place on the witness stand a clearly marked copy of each exhibit that counsel expects to have the witness refer to during his or her direct examination. Immediately before beginning cross-examination, counsel conducting cross-examination shall do the same with any additional exhibits to be referenced on cross.

6. If counsel intends to have the witness draw diagrams or put markings on visual exhibits or diagrams prepared by the party calling the witness, the witness shall do so before taking the stand. Once on the stand, the witness shall adopt the diagrams and/or markings and explain what they represent. If the diagram or visual exhibit is prepared by the opposing party, the witness shall not make any markings on the diagram or visual exhibit without leave of the Court.

7. A witness or exhibit not listed in the joint pretrial conference statement may not be called or used without good cause. This rule does not apply to true rebuttal witnesses (other than experts). Defense witnesses are normally considered case-in-chief witnesses, not "rebuttal" witnesses.

USE OF DEPOSITIONS TO IMPEACH OR SHORT READ-INS

1. Depositions used at trial for impeachment shall comply with the following procedure:

a. On the first day of trial, bring the original and clean copies of any deposition(s) intended to be used. A sealed original copy shall be provided to the Judge. b. The first time a deposition is read, counsel should state the deponent's name, the date of the deposition, and the name of the lawyer asking the question. If the deposition was a Rule 30(b)(6) deposition, counsel should so state. c. When counsel reads a passage into the record, counsel should simply say, for example, "I wish to read in page _____, lines _____ to _____ from the witness's deposition." A brief pause will be allowed for any objection. d. Counsel should then proceed by stating "question" and reading the question exactly, then stating "answer" and reading the answer exactly. Stating "question" and "answer" is necessary so that the court reporter, the Court, and the jury (in a jury trial) can follow who was talking at the deposition. e. Rather than reading a passage, counsel is free to play a videotaped version of the passage, but counsel must have a system for immediate display of the precise passage.

DEPOSITION DESIGNATIONS

1. The following procedure applies only to witnesses who appear by deposition. It does not apply to live witnesses whose depositions are read in while they are on the stand. To prepare designated deposition testimony, counsel shall photocopy the cover page, the page where the witness is sworn, and each page from which any testimony is proffered, including pages containing a counter-designation made by opposing counsel. Counsel should redact objections or colloquy unless needed to understand the question. In addition, counsel should redact any testimony that has not been designated or any testimony to which an objection has been made and sustained by the Court. Any corrections must be interlineated and references to exhibit numbers must conform to the trial numbers. The finished packet should then be the actual script and should smoothly present the identification and swearing of the witness and testimony desired.

2. Counsel is free to play a videotaped version of any deposition testimony, but counsel must have a system for immediate display of the precise testimony omitting any properly redacted passages.

EXHIBITS

1. Use numbers only, not letters, for exhibits, preferably the same numbers as were used in depositions. Blocks of numbers should be assigned to fit the need of the case (e.g., Plaintiff has 1 to 100, Defendant A has 101 to 200, Defendant B has 201 to 300, etc.). A single exhibit should be marked only once. If the plaintiff has marked an exhibit, then the defendant should not re-mark it. Different versions of the same document, e.g., a copy with additional handwriting, must be treated as different exhibits. To avoid any party claiming "ownership" of an exhibit, all exhibits shall be marked and referred to as "Trial Exhibit No. _____," not as "Plaintiff's Exhibit" or "Defendant's Exhibit." If an exhibit number differs from that used in a deposition transcript, however, then the latter must be conformed to the new trial number if and when the deposition testimony is read (so as to avoid confusion over exhibit numbers).

2. Exhibits are not to be filed but rather shall be submitted to chambers (two sets). Exhibits must be premarked. In addition, one set of exhibits must be tagged. Exhibits shall be three-hole punched and shall be submitted in binders. Sample tags may be obtained from the Courtroom Deputy and are attached as Exhibit A hereto.

3. Parties must consult with each other and with the Courtroom Deputy at the end of each trial date and compare notes as to which exhibits are in evidence and any limitations thereon. If there are any differences, parties should bring them promptly to the Court's attention.

4. In a jury trial, before the case goes to the jury, parties must confer with the Courtroom Deputy to make sure the exhibits going to the jury room are all in evidence and in good order. Parties may, but are not required to, jointly provide a revised list of all exhibits actually in evidence (and no others) stating the exhibit number and a brief, non-argumentative description (e.g., letter from A to B, dated August 17, 1999). This list may go into the jury room to help the jury sort through exhibits. In a bench trial, parties may follow a similar procedure to help the Court sort through exhibits.

OBJECTIONS

1. Counsel shall stand when making objections and briefly state the basis of the objection.

2. Counsel shall not make speaking objections.

3. There can be only one lawyer per witness per party for all purposes, including objections.

4. In a jury trial, sidebar conferences are discouraged. The procedures outlined in these guidelines should eliminate the need for most sidebars.

5. In a jury trial, to maximize jury time, parties must alert the Court in advance of any problems that will require discussion outside the presence of the jury so that the conference can be held before court begins or after the jury leaves for the day.

SETTLEMENTS AND CONTINUANCES

1. Shortly before trial or a final pretrial conference, parties occasionally wish jointly to advise the Courtroom Deputy that a settlement has been reached and seek to take the matter off calendar, but it turns out later that there was only a settlement "in principle" and disputes remain. Cases, however, cannot be taken off calendar in this manner. Unless and until a legally binding settlement is reached, all parties must be prepared to proceed with the final pretrial conference as scheduled and to proceed to trial on the trial date, or face dismissal of the case for lack of prosecution or entry of default judgment. To facilitate settlement, the Court is available to place the material terms of a settlement on the record. Only an advance continuance expressly approved by the Court will release parties from their obligation to proceed to trial. If parties expect that a settlement will be final by the time of trial or the final pretrial conference, they should notify the Court immediately in writing or, if it occurs over the weekend before the trial or conference, by voicemail to the Courtroom Deputy. The Court will attempt to confer with the parties as promptly as circumstances permit to determine if a continuance will be in order or if it can assist the parties in putting the settlement on the record. Pending such a conference, however, parties must prepare and make all filings and be prepared to proceed with trial.

2. Civil Local Rule 40-1 provides that jury costs may be assessed as sanctions for failure to provide the Court with timely written notice of a settlement. Please be aware that any settlement reached on the day of trial, during trial, or at any time after the jury or potential jurors have been summoned will normally require the parties to pay juror costs.

FootNotes


1. Indeed, the cases Bayer cites in support of such a proposition do not even discuss declaratory relief.
2. Bayer's analysis of Bradbury, originally cited by Onyx, is similarly flawed. See Reply at 9 (citing Bradbury v. Phillips Petroleum Co., 815 F.2d 1356, 1364 (10th Cir.1987)). Bayer seeks to distinguish Bradbury based on the fact that the prior conduct at issue in that case — which the court found admissible to show the absence of mistake or accident — had resulted in compensable damages. Yet Bradbury's analysis does not turn on the fact that the defendant had paid damages to past complainants. Indeed, such a claim is nonsensical because the current plaintiff was not asserting any right to, or harm from, those previous acts. Thus, such conduct was admissible despite the fact that it did not directly support any damage claim or independent cause of action by the plaintiff. Rather, the key to the dispute was that the defendant had engaged in other, relevant bad acts, regardless of whether each of those acts were legally cognizable claims, that indicated a pattern of bad conduct sufficient to justify punitive damages.
3. In its reply, Bayer makes the cursory argument that all of Onyx's claims actually sound in contract, and that therefore its tort claims are not viable. See Reply at 11 and n. 4. However, Bayer has not moved for, nor has the Court granted, dismissal or summary judgment on this basis. Thus, the fact is that Onyx's tort claims remain in the litigation; Bayer's cursory challenge to their viability at this late hour is unpersuasive. Similarly, Bayer appears to suggest that because the parties dispute whether a fiduciary duty exists, Onyx should be precluded from introducing evidence that might tend to show breach of such a duty. See Reply at 11 n. 4. This argument is meritless because it presumes Bayer will prevail on a disputed issue.
4. In its summary judgment briefing, Bayer argued that Onyx had to prove each source of damages — the Breast AI and the CRC — separately, and therefore that it could not use the combined 80% probability of one indication receiving approval to establish reasonable certainty. See Reply ISO MSJ, Docket No. 106, at 13 n.11. 1However, California law is clear that a party must only prove the fact of damages to a reasonable certainty; it does not mandate that a party prove each individual source of damages separately, as long as all of those sources stem from the defendant. Israel v. Campbell, 163 Cal.App.2d 806, 816, 330 P.2d 83 (Cal.App.1958) (discussing difficulty of awarding damages when some damages may have been caused by defendant and others may not be defendant's responsibility, but finding that problem did not apply where "[r]espondent's damages came from only one source, namely, appellant's default"); see also Guntert & Zimmerman Const. Div., Inc. v. S.G.M.E. Usine Moser S.A., No. C-88-3866, 1992 WL 12602677, at *4 (N.D.Cal. June 3, 1992) ("Although certainty as to the fact of damages must exist, a more liberal rule is applied in determining the amount of the damages."). Thus, if Onyx is able to present evidence at trial sufficient to demonstrate with reasonable certainty that one of the indications would succeed, whether it can prove that both would succeed goes more to the amount, rather than the existence, of damages. For those determinations, California uses a liberal evidentiary rule. Grupe v. Glick, 26 Cal.2d 680, 691-93, 160 P.2d 832 (Cal.1945); California Lettuce Growers v. Union Sugar Co., 45 Cal.2d 474, 486-87, 289 P.2d 785 (1955) ("[W]hen it clearly appears that a party has suffered damage a liberal rule should be applied in allowing a court or jury to determine the amount, and that, given proof of damage, uncertainty as to the exact amount is no reason for denying all recovery.") (quotation omitted); Hunt Foods, Inc. v. Phillips, 248 F.2d 23, 33 (9th Cir.1957) (restating California rule); Dillingham-Ray Wilson v. City of Los Angeles, 182 Cal.App.4th 1396, 1406, 106 Cal.Rptr.3d 691 (2010) (same); see also Macken v. Martinez, 214 Cal.App.2d 784, 790, 29 Cal.Rptr. 867 (1963) ("As defendant's wrongful conduct made the exact ascertainment of damages difficult, he cannot complain because the court must make an estimate of the damage and not an exact computation, provided, of course, that the estimate is a reasonable one."); McConnell v. Corona City Water Co., 149 Cal. 60, 66, 85 P. 929 (Cal.1906) ("It is no objection to ... recovery that [damages] cannot be directly and absolutely proved."). "It is within the sound discretion of the trier of fact to select the formula most appropriate to compensate the injured party." Marsu, B.V. v. Walt Disney Co., 185 F.3d 932, 938, 939 (9th Cir.1999) (finding that the court had exercised its discretion appropriately by "considering several possible theories for determining damages" and "declining to award compensation where it felt calculations were impermissibly speculative") (citing United States Liab. Ins. Co. v. Haidinger-Hayes, Inc., 1 Cal.3d 586, 599, 83 Cal.Rptr. 418, 463 P.2d 770 (1970)).
Source:  Leagle

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