United States Court of Appeals
                         FOR THE EIGHTH CIRCUIT
                                 ___________

                                 No. 99-3431
                                 ___________

Delores F. Turner;                       *
Russell Turner,                          *
                                         *
            Plaintiffs - Appellants,     *
                                         *
      v.                                 *
                                         *
Iowa Fire Equipment Company,             *
an Iowa Corporation,                     *
                                         *
            Defendant - Appellee.        *
                                         * Appeal from the United States
_______________________________ * District Court for the Western
                                         * District of Missouri
Iowa Fire Equipment Company,             *
                                         *
            Third Party Plaintiff -      *
            Appellee,                    *
                                         *
      v.                                 *
                                         *
Kidde-Fenwal, Inc.                       *
                                         *
            Third Party Defendant -      *
            Appellee.                    *
                                    ___________

                           Submitted: May 11, 2000

                                Filed: September 22, 2000
                                 ___________
Before RICHARD S. ARNOLD, HANSEN, and BYE, Circuit Judges.
                           ___________

BYE, Circuit Judge.

       Delores and Russell Turner appeal the adverse grant of summary judgment in
their personal injury action1 against Iowa Fire Equipment Company (Iowa Fire). The
district court,2 after excluding the causation opinion of Delores Turner's treating
physician, granted summary judgment on all claims brought by the Turners. We affirm.

                                   BACKGROUND

      Because this is an appeal from the grant of a summary judgment, we view the
evidence in the light most favorable to the Turners. We also give the Turners the
benefit of all reasonable inferences to be drawn from the evidence. See Lindsey v.
Jewels by Park Lane, Inc., 

, 1091 (8th Cir. 2000).

       Delores Turner worked in the deli area of the Hy-Vee Store in Trenton,
Missouri. On January 6, 1995, Iowa Fire performed a routine inspection of the deli's
fire suppression equipment, which included an extinguisher system located in the hood
above the grill where Delores worked. Before the Iowa Fire employees left, the system
accidentally activated. A white, powdery substance composed primarily of sodium
bicarbonate (baking soda) discharged throughout the deli, covering Delores. She



      1
       Russell's sole claim is for loss of consortium as the result of injuries suffered by
Delores, his wife.
      2
      The Honorable Fernando J. Gaitan, Jr., United States District Judge for the
Western District of Missouri.

                                           -2-
attempted to wash the powder off her skin, then returned to work. The powder still
lingered in the air.

      Delores experienced shortness of breath, itchy skin, and a headache, which
prompted her to call her family physician about an hour after the discharge. He
recommended that she take Benadryl. She did. Delores then finished her shift,
continuing to breathe in the substance for several more hours.

       Delores developed a skin rash after the exposure. At various times during the
ensuing month, Delores suffered from blisters in her mouth and nose, black discharges
from her nose, head pain, and shortness of breath. She also spit up green mucus.
Persistent nose bleeds, occurring as often as two or three times a day, started about a
month later. Delores discussed these symptoms with her family physician on February
10, 1995, during a previously scheduled appointment on an unrelated matter. Her
physician told her she should see a specialist, but did not refer her to another doctor.



       Following the visit to her family physician, Delores requested her employer to
provide her with a referral to a specialist. Her employer's workers' compensation
carrier selected Dr. David Hof, a specialist in pulmonary diseases. Dr. Hof began
treating Delores in March 1995. Dr. Hof diagnosed Delores as suffering from a




                                          -3-
hyperreactive airway disorder, similar in nature to either reactive airways dysfunction
syndrome (RADS)3 or occupational asthma (OA)4.

       Delores continued to suffer from respiratory problems, including shortness of
breath and hypersensitivity to certain airborne agents, such as perfumes, smoke, and
cleaning agents used at home and work. Dr. Hof felt that the condition was particularly
aggravated by cleaning agents used at the deli, and ultimately recommended that
Delores take some time off from work to allow her airways to heal.

       In November 1997, Delores brought this personal injury action against Iowa Fire
to recover for her lost wages and injuries, including her ongoing respiratory problems.
Iowa Fire brought a third-party action against Kidde-Fenwal, Inc. (Kidde-Fenwal), the
manufacturer of the fire extinguisher involved.

      The parties deposed Dr. Hof, who proffered his opinion that Delores's reactive
airways disorder was caused by her exposure to the chemicals from the fire


      3
        RADS is a reactive airways disease usually characterized by a single massive
exposure to an inhaled irritant, with an immediate onset of intense respiratory
difficulties. Dr. Hof explained that his diagnosis did not fit cleanly into the definition
of RADS because Delores had a single massive exposure to an inhaled substance, but
she experienced a somewhat delayed onset of significant respiratory difficulties.
      4
        OA generally refers to any asthmatic condition caused by exposure to
sensitizing agents in the workplace. Specifically, OA also describes the asthma caused
by repeated micro-exposures to a workplace irritant over a variable period of time. Dr.
Hof explained that his diagnosis did not fit cleanly into that definition of OA. Although
Delores experienced a delayed onset of significant respiratory problems (typical of
OA), her symptoms followed a single massive exposure rather than repeated micro-
exposures. In addition, Delores did not respond to short-acting bronchodilators
typically used to treat OA, but did respond to anti-inflammatory drugs typically used
to treat RADS.

                                           -4-
extinguisher discharge. Dr. Hof based his opinion in part upon the medical history he
obtained from Delores (indicating that she had not suffered respiratory problems prior
to the fire extinguisher incident), and in part upon the temporal relationship between the
fire extinguisher incident and the onset of symptoms.

       Dr. Hof acknowledged, however, that he had not determined whether any other
factors may have caused or contributed to Delores's respiratory problems, such as
repetitive exposure in the workplace to flour dust, or ammonia-based cleaning products
(both shown to be responsible for causing OA), or repetitive exposure to fumes,
chemicals, or cigarette smoke at home (Russell Turner smoked).

      Dr. Hof also acknowledged that he had made no direct effort to determine what
caused Delores's medical condition, or what specific ingredient in the extinguisher
could have caused a reactive airway disorder:

      Q.     Is it a fair statement that as a treating provider you're not
             nearly as concerned as to what caused specifically the
             respiratory complaints to initiate, rather, you are in the role
             of someone who is trying to treat and limit or eliminate the
             complaints; is that right?

      Hof: That's correct.

             ...

      Q.     And what you're telling us today is that you made no
             specific effort to look at, for example, the ingredients in the
             product to see which of those ingredients might have caused
             airway or respiratory irritation to De Turner, correct?

      Hof: No, I did not.




                                           -5-
             ...

      Q.     Is there some reason that you haven't . . . undertaken any
             kind of analysis to determine whether the ingredients in this
             product have ever been shown to produce OA or RADS?

      Hof: That's not my job definition.

      Q.     And that's because you're the treating physician as opposed
             to someone who is charged with ascertaining the cause of
             the complaints; is that right?

      Hof: You're very astute.

       Not until his deposition (March 1999) did Dr. Hof proffer the opinion that baking
soda could have caused the reactive airway disorder. Until then, Dr. Hof had only once
identified a specific substance as the likely cause of Delores's condition. In an early
(March 21, 1995) letter to the workers' compensation insurer, Dr. Hof stated that

      I have reviewed your note of March 17, listing several of the agents to
      which [Delores] was exposed in January. The NH4H2PO4 appears to be
      the agent that would be most likely to injure her airways, releasing both
      a phosphorous acid and ammonia, which can be quite irritable to the
      lining of the airways, combining with the water of the lining, producing
      an acid burn topically, which could cause enough chronic inflammatory
      injury to result in her present problems.

       Dr. Hof relied upon a Material Safety Data Sheet (MSDS) sent to him by the
workers' compensation insurer. The MSDS applied to an extinguisher manufactured
by Ansul Fire Protection, not the Kidde-Fenwal extinguisher involved here. Both
Kidde-Fenwal and Ansul extinguishers are composed primarily of baking soda, and
neither contains NH4H2PO4. The Ansul MSDS listed NH4H2PO4 under "Physical
Hazards" (agents that are incompatible with the fire extinguisher's ingredients). Dr. Hof



                                          -6-
apparently misread the Ansul MSDS and concluded that NH4H2PO4 was an ingredient,
rather than a hazardous combinant.

      Only when Dr. Hof was confronted with the mistake during his deposition did
he conclude that exposure to baking soda could cause respiratory problems:

      The only other thing I could also think that I haven't said is that I would
      think common baking soda in a large enough concentration could
      probably combine with the airway water and produce carbonic acid that
      could be irritating to the surface.

       Experts testifying on behalf of Iowa Fire and Kidde-Fenwal indicated that baking
soda never becomes acidic when mixed with moisture (but rather weakly alkaline), and
that baking soda would not burn or irritate tissue when mixed with moisture.

       Iowa Fire and Kidde-Fenwal brought a joint motion to strike Dr. Hof's opinion
that baking soda caused Delores Turner's reactive airway disorder. They contended
that Dr. Hof's opinion was not scientifically reliable under the standards set forth in
Daubert v. Merrell Dow Pharm., Inc., 

, 593-94 (1993).

      The Turners responded by contending that Daubert did not apply to Dr. Hof's
causation opinion because he was a treating physician/fact witness. The Turners also
argued that, even if Daubert applied, Dr. Hof's opinion was based on a differential
diagnosis and therefore should be admitted. The Turners also presented literature that
purportedly establishes a sufficient link between baking soda and respiratory problems,
thereby rendering Dr. Hof's opinion scientifically reliable.

      As the basis for the scientific link between baking soda and respiratory problems,
the Turners offered a Poisondex reference for sodium bicarbonate stating that
"[p]ulmonary irritation may occur following inhalation." The Turners also presented


                                          -7-
an abstract of two case reports which suggested a link between RADS and exposures
to high levels of "nonimmunogenic irritants." Finally, the Turners relied upon the
MSDS for the Kidde-Fenwal fire extinguisher, which said "[b]reathing dust may irritate
the noise [sic] and throat and cause coughing and chest discomfort." The MSDS also
stated that "Respiratory Disease including Asthma and Emphysema" were medical
conditions "generally aggravated by exposure." Dr. Hof did not rely upon any of those
items to form his opinion that baking soda caused Delores Turner's reactive airway
disorder.

      The district court concluded that Dr. Hof's causation opinion did not satisfy
Daubert's standards of scientific reliability, and granted the motion to strike the opinion.
Having excluded Dr. Hof's causation opinion, the district court further concluded that
no other evidence established a causal connection between the extinguisher exposure
and Delores's injuries, and granted summary judgment dismissing all of the Turners'
claims.

                                     DISCUSSION

I.     Exclusion of the Causation Opinion

         We review the district court's exclusion of expert testimony for abuse of
discretion. See Jaurequi v. Carter Mfg. Co., 

, 1081 (8th Cir. 1999).

       The Turners contend that, because Dr. Hof testified as a treating physician,
Daubert does not apply to his causation opinion. We disagree. Daubert ensures that
all expert testimony is scientifically reliable before being submitted to the jury. A
treating physician's expert opinion on causation is subject to the same standards of
scientific reliability that govern the expert opinions of physicians hired solely for
purposes of litigation. Cf. Kumho Tire Co., Ltd. v. Carmichael, 

, 151


                                            -8-
(1999) (holding that Daubert applies even when an expert's opinion relies on skill- or
experience-based observation).

       The Turners also contend that Dr. Hof performed a differential diagnosis which
supports his causation opinion, and that a differential diagnosis is a scientific
methodology or technique that satisfies Daubert. Daubert set forth four factors to guide
district courts in resolving admissibility questions:

      (1)    whether the expert's methodology has been tested;
      (2)    whether the technique has been subjected to peer review and
             publication;
      (3)    whether the technique has a known or knowable rate of
             error; and
      (4)    whether the technique has been generally accepted in the
             proper scientific community.

See 

.

      Most circuits have held that a reliable differential diagnosis satisfies Daubert and
provides a valid foundation for admitting an expert opinion. The circuits reason that
a differential diagnosis is a tested methodology, has been subjected to peer
review/publication, does not frequently lead to incorrect results, and is generally
accepted in the medical community. See Westberry v. Gislaved Gummi AB, 

, 262-63 (4th Cir. 1999) (collecting cases); but see Moore v. Ashland Chem., Inc.,

, 277-79 (5th Cir. 1998) (en banc), cert. denied, 

(1999)
(concluding that the district court did not abuse its discretion in excluding causation
opinion based on differential diagnosis). We agree that a medical opinion about
causation, based upon a proper differential diagnosis, is sufficiently reliable to satisfy
Daubert.




                                           -9-
      In this case, however, Dr. Hof acknowledged that the differential diagnosis he
performed was for the purpose of identifying Delores Turner's condition, not its cause.
He admitted that he made no attempt to consider all the possible causes, or to exclude
each potential cause until only one remained, or to consider which of two or more non-
excludable causes was the more likely to have caused the condition.

       As a treating physician, Dr. Hof wanted to identify Delores Turners' condition
so he could treat it. Dr. Hof's diagnosis was, we believe, one which the medical
community more properly identifies as "differential," see, e.g., Stedman's Medical
Dictionary 474 (26th ed. 1995) (identifying differential diagnosis as a systematic
comparison of symptoms to determine which of two or more conditions is the one from
which a patient is suffering), rather than the type of causal diagnosis which the legal
community calls "differential," see, e.g., 

(identifying
differential diagnosis as a technique that identifies the cause of a medical condition by
eliminating the likely causes until the most probable cause is isolated).

       Unlike his diagnosis of condition, Dr. Hof's causation opinion was not based
upon a methodology that had been tested, subjected to peer review, and generally
accepted in the medical community. Significantly, Dr. Hof did not systematically rule
out all other possible causes. He was clearly more concerned with identifying and
treating Delores's condition than he was with identifying the specific substance that
caused her condition. Dr. Hof arrived at his opinion about baking soda more as an
afterthought, in an ad hoc manner, only after being informed that he had misidentified
NH4H2PO4 as one of the extinguisher's ingredients. Therefore, although recognizing
that a causation opinion based upon a proper differential diagnosis (one that
systematically rules out other possible causes) satisfies Daubert, we conclude that the
district court did not abuse its discretion in excluding Dr. Hof's particular causation
opinion in this case.




                                          -10-
       The Turners next contend that Dr. Hof's causation opinion should be admitted
because reliable, scientific literature establishes a causal link between baking soda and
respiratory disease. The Turners rely on a Poisondex reference for sodium bicarbonate,
a case report abstract, and the MSDS for the Kidde-Fenwal extinguisher.

        We first note, as has the Third Circuit, that "we do not believe that a medical
expert must always cite published studies on general causation in order to reliably
conclude that a particular object caused a particular illness." Heller v. Shaw Indus.,
Inc., 

, 155 (3rd Cir. 1999); see also 

(holding
that a reliable differential diagnosis alone provides valid foundation for causation
opinion, even when no epidemiological studies, peer-reviewed published studies,
animal studies, or laboratory data are offered in support of the opinion). The first
several victims of a new toxic tort should not be barred from having their day in court
simply because the medical literature, which will eventually show the connection
between the victims' condition and the toxic substance, has not yet been completed.
If a properly qualified medical expert performs a reliable differential diagnosis through
which, to a reasonable degree of medical certainty, all other possible causes of the
victims' condition can be eliminated, leaving only the toxic substance as the cause, a
causation opinion based on that differential diagnosis should be admitted.

      In this case, the Turners relied upon a Poisondex reference that indicates
"[p]ulmonary irritation may occur following inhalation [of baking soda]." However, Dr.
Hof did not rely upon the Poisondex reference in formulating his opinion. Moreover,
the Poisondex reference is not specific enough to establish a causal link between
Delores Turner's hyperreactive airway disorder and baking soda.

       The Turners also presented a case report abstract that suggests a link between
RADS and exposures to high levels of "nonimmunogenic irritants." Again, Dr. Hof did
not rely upon that case report abstract to form his opinion, and therefore did not discuss


                                          -11-
what the abstract identifies as "nonimmunogenic irritants." The Turners presented no
evidence demonstrating that baking soda could be considered a "nonimmunogenic
irritant."5

       The Turners also relied upon the MSDS for the Kidde-Fenwal extinguisher. The
MSDS indicates that breathing dust may irritate the nose and throat, and that exposure
to the extinguisher's contents may aggravate (not cause) respiratory diseases such as
asthma and emphysema. Again, Dr. Hof did not rely upon the Kidde-Fenwal MSDS
to formulate his opinion; nothing in the record demonstrates what scientific tests or
information Kidde-Fenwal used to generate its MSDS. See Moore v. Ashland 

(holding that an MSDS has limited scientific value when it is unknown
what tests were conducted in generating the MSDS).

       Even if we assumed that the Poisondex reference, the case report abstract, and
the MSDS, considered in combination, were sufficiently reliable to establish a causal
link between baking soda and respiratory disease, those items would not save Dr. Hof's
causation opinion from exclusion. Dr. Hof simply did not rely upon those items in
formulating his opinion, and Dr. Hof did not scientifically eliminate other potential
causes of Delores Turner's condition. In other words, while the literature relied upon
by the Turners may "rule in" baking soda as a possible cause of respiratory disease, Dr.
Hof failed to "rule out" all other possible causes. See National Bank of Commerce of
El Dorado v. Associated Milk Producers, Inc., 

, 963 (E.D. Ark.
1998), aff'd, 

(8th Cir. 1999) (recognizing that an expert must "rule in" the
suspected cause as well as "rule out" other possible causes).



      5
       Case reports are generally not considered reliable evidence of causation. See,
e.g., Willert v. Otho Pharm. Corp., 

, 981 (D. Minn. 1998); Casey v.
Ohio Med. Prod., 

, 1385 (N.D. Cal. 1995); Schmaltz v. Norfolk &
Western Ry. Co., 

, 1122 (N.D. Ill. 1995).

                                          -12-
       We conclude that the district court did not abuse its discretion by excluding Dr.
Hof's opinion that Delores Turner's exposure to baking soda caused her hyperreactive
airway disorder.

II.   Summary Judgment

     We review the district court's grant of summary judgment de novo. Stuart v.
General Motors Corp., 

, 630 (8th Cir. 2000).

      The district court concluded that, without Dr. Hof's causation opinion, the
Turners could not prove their claims under Missouri law. See Chism v. W.R. Grace
& Co., 

, 991 (8th Cir. 1998) (explaining the causal requirements of
Missouri law). We agree.

       Under Missouri law, "a causal connection between an event and an injury may
be inferred in cases in which a visible injury or a sudden onset of an injury occurs."
Soper v. Bopp, 

, 157 (Mo. Ct. App. 1999). However, when the injury
is a "sophisticated" one, i.e., requiring surgical intervention or other highly scientific
technique for diagnosis, proof of causation is not within the realm of lay understanding
and must be established through expert testimony. See 

complaint sought recovery for the following injuries: asthma,
reactive airways disease, airway hyperreactivity, and impaired function and damage to
the respiratory system (nose, mouth, throat, lungs, and airway passages). Those
injuries were all "sophisticated" ones, where any causal connection to the fire
extinguisher exposure would be outside the realm of lay understanding. Without Dr.
Hof's opinion that the fire extinguisher exposure caused the respiratory injuries, the
Turners cannot prove causation.




                                          -13-
       The Turners also sought recovery for the "mental and emotional upset and
anxiety and sleeplessness" that Delores allegedly suffered as a result of her respiratory
injuries. Under Missouri law, emotional distress injuries are considered "sophisticated"
ones, outside the realm of lay understanding. Those injuries must be established
through expert testimony as well. See 

Turners claim that, even without Dr. Hof's opinion linking the fire
extinguisher exposure to Delores's respiratory problems, they can nevertheless prove
that Delores suffered a "physical assault" on her body when she was exposed to the
extinguisher's contents. The Turners contend that they should at least be allowed to
proceed to trial for the injuries caused by that "physical assault."

       We agree. If Delores suffered "visible" injuries as a result of the exposure, her
proof of causation does not necessarily depend on expert medical testimony. See 

"visible" injury that Delores suffered, however, was a skin rash. The Turners'
complaint does not include a claim for skin rash, or any other injuries considered
"visible" under Missouri law. All the injuries alleged in the Turners' complaint are
considered "sophisticated," requiring expert testimony to prove causation.

      We conclude that the district court did not err in granting summary judgment,
and therefore affirm.

RICHARD S. ARNOLD, Circuit Judge, dissents.

      A true copy.

             Attest:

                 CLERK, U.S. COURT OF APPEALS, EIGHTH CIRCUIT.


                                          -14-